Zuber Says That Before This Discovery, Little Had Been Known About The Roles Of The Individual Eftfs In Initiating Retina Formation.

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Zuber says that before this discovery, little had been known about the roles of the individual EFTFs in initiating retina formation. This discovery now gives us the minimal recipe for making retinal cells, he said. no dataIn their study, the team used frog embryos whose retinas develop in a similar manner and contain the same retinal cell types as those of the human retina. They found that only two of the seven EFTFs, Tbx3 and Pax6, were necessary to start the process of eye formation. Zuber noted the other EFTFs are still required to form a normal eye, but may not be required for the very first steps. The pluripotent stem cells used in their study have the potential to form many cell types in the body. Tbx3 and Pax6 however, provided all the instructions necessary for the cells to form retina. Consequently, with further study, their discovery may also be translated into generating retinal cells in culture for therapeutic use. Viczian says that an important goal of their research is to identify the genes that are required to transform pluripotent stem cells into retinal progenitor cells and differentiated retinal cells in the laboratory.

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